3 forms of ZOMIG


ZOMIG is a prescription medication used for the treatment of migraine headaches in adults. ZOMIG is not for the prevention of migraines. ZOMIG is not for other types of headaches.

Find out about the 3 forms of ZOMIG

Use this information to help talk with your health care professional about the 3 forms of ZOMIG and if ZOMIG could be right for you.

See below for Important Safety Information about ZOMIG.

Learn more about each form:

Or use the Formulation Finder—an easy-to-use chart about the 3 forms of ZOMIG.

Click on each tab for information from clinical studies about each form.

  • ZOMIG® Tablets
    Type of headache Moderate or severe migraine
    Dosage ZOMIG Tablets 2.5 mg or placebo (Results in two studies)
    Percentage of patients with headache response at 1 hour after treatment* Study 1:
    44% of patients taking ZOMIG Tablets 2.5 mg
    26% of patients taking placebo

    Study 2:
    33% of patients taking ZOMIG Tablets 2.5 mg
    26% of patients taking placebo
    Percentage of patients with headache response at 2 hours after treatment* Study 1:
    65% of patients taking ZOMIG Tablets 2.5 mg
    34% of patients taking placebo

    Study 2:
    62% of patients taking ZOMIG Tablets 2.5 mg
    36% of patients taking placebo
    Percentage of patients with headache response at 4 hours after treatment* Study 1:
    75% of patients taking ZOMIG Tablets 2.5 mg
    32% of patients taking placebo

    Study 2:
    70% of patients taking ZOMIG Tablets 2.5 mg
    37% of patients taking placebo
    Number of patients in study (number of patients taking Zomig and number of patients taking placebo) Study 1: 260 and 121

    Study 2: 178 and 92
    Dosage ZOMIG Tablets 5.0 mg or placebo (Results in 4 studies)
    Percentage of patients with headache response at 1 hour after treatment* Study 1:
    44% of patients taking ZOMIG Tablets 5.0 mg
    26% of patients taking placebo

    Study 3:
    44% of patients taking ZOMIG Tablets 5.0 mg
    16% of patients taking placebo

    Study 4:
    34% of patients taking ZOMIG Tablets 5.0 mg
    21% of patients taking placebo

    Study 5:
    24% of patients taking ZOMIG Tablets 5.0 mg
    15% of patients taking placebo
    Percentage of patients with headache response at 2 hours after treatment* Study 1:
    67% of patients taking ZOMIG Tablets 5.0 mg
    34% of patients taking placebo

    Study 3:
    66% of patients taking ZOMIG Tablets 5.0 mg
    19% of patients taking placebo

    Study 4:
    59% of patients taking ZOMIG Tablets 5.0 mg
    44% of patients taking placebo

    Study 5:
    62% of patients taking ZOMIG Tablets 5.0 mg
    15% of patients taking placebo
    Percentage of patients with headache response at 4 hours after treatment* Study 1:
    77% of patients taking ZOMIG Tablets 5.0 mg
    32% of patients taking placebo

    Study 4:
    80% of patients taking ZOMIG Tablets 5.0 mg
    60% of patients taking placebo
    Number of patients in study (number taking ZOMIG and number taking placebo) Study 1: 245 and 121

    Study 3: 179 and 88

    Study 4: 491 and 55

    Study 5: 21 and 20

    *Headache response was defined as a moderate or severe headache improving to mild or no pain.

    • In the only direct comparison of ZOMIG 2.5 mg Tablets and ZOMIG 5 mg Tablets, there was little added benefit from the larger dose, but side effects were generally increased at 5 mg. Patients should, therefore, be started on a 2.5 mg or lower dose.

    ZOMIG Tablets: convenience in a conventional tablet

    • Provides migraine relief in tablet form
    • Available in 2.5 mg and 5 mg doses
  • ZOMIG-ZMT®
    Type of headache Moderate or severe migraine
    Dosage ZOMIG-ZMT 2.5 mg or placebo
    Percentage of patients with headache response at 1 hour after treatment* 45% of patients taking ZOMIG-ZMT 2.5 mg
    19% of patients taking placebo
    Percentage of patients with headache response at 2 hours after treatment* 63% of patients taking ZOMIG-ZMT 2.5 mg
    22% of patients taking placebo
    Percentage of patients with headache response at 4 hours after treatment* 51% of patients taking ZOMIG-ZMT 2.5 mg
    14% of patients taking placebo
    Number of patients in study 231 of patients taking ZOMIG-ZMT 2.5 mg
    239 of patients taking placebo

    *Headache response was defined as a moderate or severe headache improving to mild or no pain.

    • A separate study evaluated 329 patients of patients taking ZOMIG-ZMT 5 mg and 341 patients of patients taking placebo. At 30 minutes, 17% of patients taking ZOMIG-ZMT 5 mg and 13% of patients taking placebo achieved a headache response*. At 1 hour 41% of patients taking ZOMIG-ZMT 5 mg and 23% of patients taking placebo achieved a headache response. And at 2 hours, these rates were 59% and 31%, respectively
    • In the only study that directly compared ZOMIG 2.5 mg and ZOMIG 5 mg, the conventional Tablets formulation was used. This study found that there was little added benefit from the larger dose, but side effects are generally increased at 5 mg. Patients should, therefore, be started on a 2.5 mg or lower dose

    ZOMIG-ZMT Orally Disintegrating Tablets: you don't need water to take it

    • Migraine relief in a form that quickly dissolves on your tongue
    • Good for situations when you can’t take your migraine medication because you don’t have water—at work or dropping the kids at school
    • A suitable option if you experience nausea caused by the migraine
    • Available in 2.5 mg and 5 mg doses
  • ZOMIG® Nasal Spray
    Type of headache Moderate or severe migraine
    Dosage ZOMIG Nasal Spray 5 mg or placebo
    Percentage of headaches with a response at 15 minutes after treatment* 11% of patients taking ZOMIG Nasal Spray 5 mg
    5% of patients taking placebo
    Percentage of headaches with a response at 2 hours after treatment* 70% of patients taking ZOMIG Nasal Spray 5 mg
    31% of patients taking placebo
    Percentage of headache with a response at 4 hours after treatment* 78% of patients taking ZOMIG Nasal Spray 5 mg
    30% of patients taking placebo
    Number of patients in study 235 of patients taking ZOMIG Nasal Spray
    226 of patients taking placebo

    *Headache response was defined as a moderate or severe headache improving to mild or no pain.

    ZOMIG Nasal Spray 5 mg

    • A great option for when you want to keep your medication handy
    • Available in a 5 mg dose

    How to use ZOMIG Nasal Spray


Formulation Finder

Find the form of ZOMIG that's best for you

ZOMIG nasal spray

Find more information about each form of ZOMIG: ZOMIG Tablets, ZOMIG-ZMT Orally Disintegrating Tablets, or ZOMIG Nasal Spray.

Approved Use and Important Safety Information for ZOMIG

Approved Use for ZOMIG

ZOMIG is a prescription medication used for the treatment of migraine headaches in adults. ZOMIG is not for the prevention of migraines. ZOMIG is not for other types of headaches.

Important Safety Information

  • Do not take ZOMIG if your headache is not a migraine
  • Do not take ZOMIG if your headache is hemiplegic or basilar migraine (If you are unsure about this, ask your doctor)
  • Do not take ZOMIG if you have heart disease, history of, or risk factors for heart disease, uncontrolled high blood pressure, circulation (blood flow) problems, or have had a stroke. Only your doctor can determine if ZOMIG is right for you
  • ZOMIG should not be used within 24 hours of another 5-HT1 agonist (triptans), ergotamine-containing or ergot-type medication (for headache), or within 2 weeks of an MAO-A inhibitor (for depression)
  • Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding because ZOMIG may not be right for you
  • ZOMIG, like other triptans, may be associated with a potentially life-threatening condition called serotonin syndrome, mainly when taken together with certain antidepressants. Inform your doctor of all your medications prior to taking ZOMIG
  • Phenylketonurics: ZOMIG-ZMT® (zolmitriptan) Orally Disintegrating Tablets contain phenylalanine, a component of aspartame
  • Safety and effectiveness of ZOMIG in pediatric patients have not been established
  • Side Effects: The most common side effects reported by patients in clinical trials with ZOMIG Nasal Spray include unusual taste, tingling sensation, skin sensitivity, and dizziness
  • Side Effects: The most common side effects reported by patients in clinical trials with ZOMIG Tablets and ZOMIG-ZMT include dizziness; tightness, pressure, pain in the neck, throat, or jaw; fatigue; tingling; drowsiness; and nausea

Talk to your doctor about prescription ZOMIG.

Click here to see the Prescribing Information for ZOMIG Tablets and ZOMIG-ZMT Orally Disintegrating Tablets Opens in new window (PDF — 194KB)

Click here to see the Prescribing Information for ZOMIG Nasal Spray Opens in new window (PDF — 122KB)

Click here to see the Important ZOMIG Product Information for Patients Opens in new window (PDF — 480KB)

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.